Diagnostic Role of Immunogenetics in Post-Vaccine Diseases  of the Central Nervous System (CNS): Preliminary Results
Associazione Universo Bambino - Italy
Massimo G. Montinari, Biagio Favoino”, Angela Roberto” * Servizio di Tipizzazione tessutale e trapianti d'organo - Azienda Ospedaliera Policlinico di Bari,  Italy  ** Ambulatorio di Virologia - Azienda Ospedaliera Policlinico di Bari, Italy
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The Mediterranean Journal of Surgery and Medecine
Abstract
We report of 30 patients with post-vaccine diseases of CNS and other organs who presented with the initial symptoms at the time of or immediately a.fter vaccines.
All patients were tested for Herpes virtis (IgG and IgM) and tissue typing (HLA A, B, C, HLA DR-DQ) to study the relationship between the development of post-vaccine CNS diseases and those antigens trying to show that an immunogenetic substrate (autoimmune type) is involved in demyeiination processes.
The comparison of our patients with formai Italian controis showed an increased presence of HLA A3 and DR-7 antigens in the former group. The occurrence of A3 and/or DR7 was observed in 22/30 patients (73.3%)

Key words: Post-vaccine disease - HLA antigens -Autoinimune disease CNS

Résumé
Cette étude rapporte l’observation de 30 patients atteints de pathologies post-vaccinaies intéressant le SNC et d’autres systèmes dans lesquels ies premiers symptòmes sont apparus concomitamment ou immédiatement après l’administration de vaccins.
Chez tous les patients on a effectué des recherches sérologiques pour les virus herpétiques (IgG et IgM) ainsi qu’une caractérisation tissulaire HLA (A,B,C) et HLA-DR-DQ afin de mettre en évidence tine corrélation possible entre l’apparition de pathologies citi SNC et ces antigènes;  autoimmunitaires du SNC cette corrélation pourrait expliquer une éventuelle base immunogénétique de type autoimrnunitaire dans les processus de démyélinisation. La comparaison statistique avec la population italienne de contròle a mis en évidence une augmentation des antigènes HLA-A3 et HLA-DR-7. On a observé la présence de A3 et/ou DR-7 chez 22/30 (73,3%) patients.

Mots-clés: Pathologies post-vaccinales - Système HLA - pathologies

Riassunto
Lo studio si riferisce all’osservazione di 30 pazienti affetti da patologie post-vaccinali con interessamento del SNC e di altri apparati nei quali i primi sintomi sono insorti in concomitanza o immediatamente dopo la somministrazione di vaccini.
Tutti i pazienti sono stati sottoposti ad indagini sierologiche per virus erpetici (IgG e IgM) nonché a tipizzazione tessutale HLA(A,B,C) e HLA-DR-DQ allo scopo di accertare una eventuale correlazione tra l’insorgenza di patologie a carico del SNC e questi antigeni tale da spiegare una possibile base immunogenetica di tipo autoimmunitario nei processi di demielinizzazione. Il confronto statistico con la popolazione italiana di controllo ha messo in evidenza un aumento degli antigeni HLA-A3 e HLA­DR-7. 
La presenza di A3 e/o DR-7 è stata osservata in 22/30 (73,3%) dei pazienti.

Parole chiave: Patologie post-vaccinali - sistema HLA - patologie autoimnuinitarie del SNC

INTRODUCTION 
CNS post-vaccine diseases are often not well studied.Recently, it has been suggested the “occurrence of CNS demyelination follwing immunisation with recombinant Hepatitis B vaccine” (1) ancl these observation have heen supported by other Investigators who reported “lack of virus and eosinophiiia following recombinant Hepatitis B vaccine” (2). These studies induced us to reevaiuate patients who presented with netirological symptoms followingn immunisation already investigated in several Itaiian and European Centres.
Med. J. Surg. Mcd. 2 (1996), 69-72

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