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L'International
Journal of Toxicology ha pubblicato uno studio
molto interessante con cui documenta negli Usa
un'alta incidenza di herpes zoster in seguito
all'introduzione nel 1995 per tutti i bambini
della vaccinazione
per la varicella.
Gary Oldman,
autore della ricerca, spiega come l'herpes zoster
fosse naturalmente eliminato dal contatto che
naturalmente si aveva con il virus della varicella
e sostiene che, eliminando sempre più dalla
circolazione il virus naturale con la
vaccinazione,ci sarà un continuo aumento di
herpes zoster (che provoca, rispetto alla
varicella, un numero di morti tre volte maggiore e
di ospedalizzazioni cinque volte maggiore) per i
prossimi 50 anni.
Per fronteggiare la grave
situazione gli epidemiologi del Cdc di Atlanta
hanno proposto di continuare con la vaccinazione
antivaricella, ma di trattare anche gli adulti con
un vaccino contro l'herpes zoster.
Ecco il testo della comunicazione e i riferimenti.
PRESS
RELEASE - Contact: Gary S. Goldman, Ph.D. - Phone:
661-944-5661 - Fax: 661-944-4483 for immediate
release
CHICKEN POX VACCINE ASSOCIATED WITH SHINGLES
EPIDEMIC
Pearblossom, CA - New research published in the
International Journal of Toxicology (IJT) by Gary
S. Goldman, Ph.D., reveals high rates of shingles
(herpes zoster) in Americans since the government's
1995 recommendation that all children receive
chicken pox vaccine. Goldman's research supports
that shingles, which results in three times as
many deaths and five times the number of
hospitalizations as chicken pox, is suppressed
naturally by occasional contact with chicken pox.
Dr. Goldman's findings have corroborated other
independent researchers who estimate that if
chickenpox were to be nearly eradicated by
vaccination the higher number of shingles cases
could continue in the U.S. for up to 50 years; and
that while death rates from chickenpox are already
very low, any deaths prevented by vaccination will
be offset by deaths from increasing shingles
disease. Another recent peer-reviewed article
authored by Dr. Goldman and published in Vaccine
presents a cost-benefit analysis of the universal
chicken pox (varicella) vaccination program.
Goldman points out that during a 50-year time span,
there would be an estimated additional 14.6
million (42%) shingles cases among adults aged
less than 50 years, presenting society with a
substantial additional medical cost burden of $4.1
billion. This translates into $80 million annually,
utilizing an estimated mean healthcare provider
cost of $280 per shingles case.
After a child has had varicella (chickenpox), the
virus becomes dormant and can reactivate later in
adulthood in a closely related disease called
shingles--both caused by the same varicella-zoster
virus (VZV). It has long been known that adults
receive natural boosting from contact with
children infected with chicken pox that helps
prevent the reactivation of shingles.
Based on Dr. Goldman's earlier communications with
the Centers for Disease Control and Prevention (CDC),
Goldman maintains that epidemiologists from the
CDC are hoping "any possible shingles
epidemic associated with the chickenpox vaccine
can be offset by treating adults with a shingles
vaccine." This intervention would substitute
for the boosting adults previously received
naturally, especially during seasonal outbreaks of
the formerly common childhood disease.
"Using a shingles vaccine to control shingles
epidemics in adults would likely fail because
adult vaccination programs have rarely proved
successful," said Goldman. "There
appears to be no way to avoid a mass epidemic of
shingles lasting as long as several generations
among adults."
Goldman's analysis in IJT indicates that
effectiveness of the chickenpox vaccine itself is
also dependent on natural boosting, so that as
chickenpox declines, so does the effectiveness of
the vaccine. "The principal reason that
vaccinees in Japan maintained high levels of
immunity 20 years following vaccination was that
only 1 in 5 (or 20%) of Japanese children were
vaccinated," he said. "So those
vaccinated received immunologic boosting from
contact with children with natural chickenpox. But
the universal varicella vaccination program in the
U.S. will nearly eradicate this natural boosting
mechanism and will leave our population vulnerable
to shingles epidemics."
For decades it was thought shingles increased with
age as older individuals' immune systems declined.
However, Goldman's new research shows this
phenomenon seemed primarily due to the fact that
older people received fewer natural boosts to
immunity as their contacts with young children
declined.
Gary S. Goldman, Ph.D. served for eight years as a
Research Analyst with the Varicella Active
Surveillance Project conducted by the Los Angeles
County Department of Health Services (LACDHS). The
project was funded by the CDC.
Contacts: Gary S. Goldman, Ph.D. Phone
661-944-5661; Fax: 661-944-4483; - Email:
pearblossominc@aol.com
About Gary S. Goldman, Ph.D.: Currently serves as
Founder and Editor-in-Chief of the peer-reviewed
medical journal Medical Veritas -
www.MedicalVeritas.com
Has recently authored five manuscripts concerning
varicella, herpes zoster, and capture-recapture
published in the Europea journal called Vaccine.
Research published in the International Journal of
Toxicology, 24(4):205-213, Universal Varicella
Vaccination: Efficacy Trends and Effect on Herpes
Zoster. Also, Vaccine, 23(25):3349-3355,
Cost-benefit analysis of universal varicella
vaccination in the U.S. taking into account the
closely related herpes zoster epidemiology.
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