Vaccinazioni per l’infanzia ed autismo
Metalli tossici dei vaccini = Autismo vedi: PDF -  dott. M. Proietti

Sentenza 2012 - Trib. Rimini su Vaccini=Autismo

IV.       DETECTION OF MERCURY IN AUTISTIC CHILDREN
In the past, hair, urine, or blood tests from autistic subjects have mostly found lead rather than mercury (Wecker et al, 1985), but this is likely due (i) to lead’s pervasiveness in our environment, coupled with autistic children’s pica tendencies and general inability to detoxify any heavy metal (LaCamera and LaCamera, 1987; Edelson & Cantor, 1998); (ii) to the difficulty in detecting Hg, especially in older children exposed early in life, since remaining mercury is sequestered in tissue; and (iii) to the greater affinity of standard chelators used in challenge tests (e.g., DMSA) for lead over mercury, making lead more readily detectable in such exams (Frackelton and Christenson, 1998).
More recently, a number of parents of younger autistic children, in whom mercury is more likely to be detectable, have reported higher than expected levels of mercury in hair, blood, and urine samples.  Cases studies are listed below, and more are in the process of documentation. Several parents have also noted improved function after chelation.

The Case Studies
We are providing data from several retrospective case studies of autistic children with associated tissue mercury burdens. 
In each case we have tried to identify potential sources of exposure, although we have notbeen able to identify the exact amounts in some cases due to inadequate documentation.  This information does not purport to be a rigid scientific study, but rather an initial effort to demonstrate that there may be a problem with mercury toxicity in children with autism. 
Our primary objective is to show that considerable amounts of mercury are found in the bodies of some autistic children. 
The data we present were derived from many sources: hair, urine and blood.  Some of the samples were baseline and others were obtained utilizing a provocative agent, either DMPS or DMSA. 
Typically a single dose of DMPS will provoke more mercury from the tissue than a single oral dose of DMSA.  Excretion levels will also vary depending on the amount of DMPS or DMSA given.  There are also variations among these factors in the case studies.

Identifier:  0001SM         Sex: M           Age: 5             DOB:  4-25-94
Prenatal and Postnatal History: Premature contractions, which required bedrest during the 2nd and 3rd trimesters. 
Scheduled C-section at term with good apgars.  Birth weight 8 lbs. 3 oz. Vomiting milk based formula, which subsided with a switch to soy formula at 2 months.
Developmental Landmarks: Completely normal development, meeting all developmental milestones until 20 months of age.  Speech present with two word phrases.
Regression and Symptoms:  At 20 months an unexplained loss of speech and eye contact (lateral gaze).  He began lining up trains, developed preservations, and showed a marked decrease in attention.  Diagnosed autistic at 26 months of age.  
Formal psychological evaluation at 30 months found expressive speech at 14-16 months, cognitive at 12-18 months, fine motor at 18 months, and play skills at 12 months.  He was described as withdrawn with alternating inattention or repetitive manipulation of objects.
Exposure Sources: He received multiple vaccines with thimerosal preservatives his first year, including influenza vaccine.
The documented exposure the first year was 136.5mcg mercury.  Mother with 1 amalgam filling and minimal dietary exposure. Child with no dietary exposure the first year of life.  Families estimated consumption of seafood 3 times monthly.
Mercury Levels:  Hair mercury 2.6 mcg with a norm reference of less than 2mcg.  DMPS provacation (3mg per kg. IV) 7-7-99 resulted in 87 mcg mercury per g urinary creatine. Intermittent treatment with oral DMSA continued for 2 months with normalization of hair mercury levels.
Response to Treatment:  Parents claim significant improvement in speech and behavior, also documented on neuropsychological evaluation on 1-14 and 1-21-00.  “His ability to use language for social purposes has clearly increased and he could maintain exchanges for several turns without excessive difficulty.  He has improved in his ability to initiate interactions and invitation to other children to play. Academic function at or above grade level.  Impressive and highly encouraging rate of progress.”

Identifier:  0002CM           Sex:   M          Age:   5          DOB:   12-1-94
Prenatal and Postnatal History: Unremarkable prenatal course.  Birth weight 8lbs.8oz.
Maintained above the 95th percentile for height and weight the first year of life.
Developmental Landmarks: All early developmental landmarks - crawling, walking, and talking - were obtained on schedule.
Regression and Symptoms:  Child went from age appropriate to severe autistic regression between 18 to 20 months.  He lost speech, eye contact and became inattentive and withdrawn. Symptoms at 3 years include extreme thirst, echolalia, toe walking, high pain threshold, sleep disturbances, hyperactivity and obsessive behaviors.
Exposure Sources:  No maternal amalgam history and minimal dietary exposure.  He received all recommended vaccines, although without manufacturer data we are unable to calculate total exposure at this time. Known exposure from hepatitis B vaccine, 37.5 mcg mercury.
Mercury Levels:  Hair mercury was 2.21ppm at 3 years and 3 months of age with a lab  reference of 0-1.5ppm.  DMPS provocation utilizing 3 mg. DMPS/kg given IV revealed:

                   46 micrograms of mercury / g creatine on 12-18-98

                   86 micrograms of mercury / g creatine on 3-25-99

                   46 micrograms of mercury / g creatine on 7-27-99

                   36 micrograms of mercury / g creatine on 9-30-99

Normal reference for urinary mercury 0-3 micrograms / g creatine.

Between DMPS infusions the child received DMSA 100 mg. orally two days a week, with glutathione 75 mg. twice daily, glycine 900 mg. on day prior to DMSA and glycine 900 mg. on DMSA treatment days.

Response to treatment: On 3-22-00 the parents reported marked behavioral improvement, particularly over the past two months.  He now responds to his name and follows instructions.  He has developed original speech without echolalia, and obsessive behaviors have declined.

Identifier:  0003HC           Sex: M              Age:  3yr. 11mo.        DOB: 4-11-96
Prenatal and Postnatal History: Prenatal history was unremarkable.  Infant was thought to be 4 weeks premature, although birth weight was that of a term infant at 8lbs. 6oz.  He developed jaundice shortly after birth and was treated with phototherapy.  He was briefly given antibiotics for a suspected infection the first 3 days of life.
Developmental Landmarks: Parents report that his development was normal until 12 months.  He was crawling but did not begin to walk until 18 months of age with the support of a walker.
Regression and Symptoms: Some concerns at 13 months, marked regression at 16 months.  Six to seven spoken words in use at 12 months were entirely lost. Vacant stares predominated and he began biting his hands.  Officially diagnosed autistic at 2 1/2 years of age.
Exposure Sources: Mother had 8 amalgams.  He also received exposure via vaccine, but total dose is not available at this time
Mercury Levels: Hair mercury at 2 years 7 months was below detection limits.  DMSA provacative protocol with 10 mg per kg per dose three times daily for three days with 24 hr urine screen for heavy metals day 2 revealed:

                      3.2 micrograms of mercury / g creatine on 6-21-99

                      28 micrograms of mercury / g creatine on 9-13-99

                      13 micrograms of mercury / g creatine  on 10-12-99

                      Normal lab reference 0-3 mcg Hg per g creatine.

Response to treatment: Parents feel certain that DMSA chelation has resulted in improvement in their son. 
They noticed almost immediate improvement during the three days of treatment along with dramatic improvement the past six months.  He is “much more with it and curious about his world”. 
Although he is still not talking, he is having frequent vocalizations.  He just started running for the first time 6 weeks ago.

Identifier:  0004WR            Sex:  M             Age:  6              DOB:  2-2-94
Prenatal and Postnatal History: Prenatal history unremarkable with the exception of breech presentation.  C-section preformed and apgars were 9 and 10. Birth weight, 8lbs.
11oz.  Normal postnatal course.
Developmental Landmarks: He easily met and exceeded all early developmental landmarks and was described as a pleasant, happy baby.
Regression and symptoms: Shortly after his first birthday he developed numerous infections and was hospitalized for a respiratory illness.  He received antibiotics, steroids, and oxygen and was discharged on day three.  By 15 months he had lost speech and interaction.  At 18 months he developed a very limited diet with bouts of bloody, culture negative diarrhea. 
Officially diagnosed autistic at 5 yrs, although he had been receiving services for autism from the school system since age 3.
Exposure sources: This child received all early vaccines with thimerosal preservative.  At 2 months of age he received 62.5 mcg of mercury which represented a 125 fold increase above EPA guidelines based on his weight.  This occurred again at 4 months, 62.5 mcg mercury and 50 mcg mercury at 6 months, 11 months 12.5mcg mercury and at 18 months, 50 mcg mercury for a total of 237.5 mcg of mercury. Mother also reports 5 dental amalgams and minimal dietary exposure. Child has never eaten fish or seafood.
Mercury Levels: Hair analysis from 20 months revealed 4.8 ppm mercury with a reference range of 0-1ppm and aluminum 40.2 with a reference of 0-9ppm. Note this sample was not sent for analysis until the child was already 5 1/2 years at which time the mother became aware of his early mercury exposure from vaccines. A subsequent analysis at 5 ½ years revealed normal levels of mercury and elevated lead 1.14 ppm with a normal reference 0-0.5, aluminum 23.2, and antimony 0.017 with reference of 0-0.03 and bismuth 0.19 with reference of 0-0.11.  Initial treatment with oral DMSA removed 17 mcg per g creatine lead with reference 0-15 mcg per g creatine. Oralcyclic chelation was continued for 5 cycles with lead again present at 15 mcg per g creatine down to normal levels at the 5th cycle.
Response to treatment:  Parents report marked improvement with each round of chelation.  The last two cycles were not as pronounced as the first 3 cycles of treatment.  An increase in spontaneous language and a general overall increase in all areas of functioning were also noted.

Identifier: 0005ZH            Sex: M               Age: 10                DOB: 5-28-89

Prenatal and Postnatal History: Unremarkable pre- and postnatal course.  Term vaginal delivery.  Pitocin given for failure to progress. Birth weight 7 lbs. 14 oz., good apgars.

Developmental Landmarks:  Mother reports he was a very alert and pleasant infant who easily obtained all his early developmental landmarks with the exception of crawling.  He progressed directly to walking at 8 ½ months. 
He began to babble and had developed some speech the first year of life, which did not progress.

Regression and Symptoms: Parents were concerned about his speech delay but attributed it to other factors. He also developed a very picky diet with a preference for starches.  He also would line up toys and repeat phrases but was not officially diagnosed autistic until 5 years of age.
Exposure Sources: Mother with multiple dental amalgams. DPT vaccine known to have mercury 25 mcg per dose at 2,4,and 6 months.  Child did eat fish sticks as a toddler but parents switched to only farm raised fish.
Mercury Levels: A 24 hour heavy metal challenge at 9 years of age removed 67 mcg of mercury. 
Unfortunately, the parents were not able to financially afford further treatment at that time.
 

Identifier: 0006MA              Sex: M            Age: 4 ½ yrs.         DOB: 8-24-95

Prenatal and Postnatal History:  Uncomplicated pregnancy, term vaginal delivery, apgars 9 and 10,  birth weight 7 lbs. 6 oz.  Quickly learned to breast feed, unremarkable postnatal history.

Developmental Landmarks:  Easily met all early developmental milestones.  Described as being very social with good eye contact. He was saying Mama, bye-bye, and babbling at 14 months.

Regression and Symptoms:  According to the parents, at 16 to 17 months he began to slide into his own world.  He stopped responding to his name and making eye contact.  He also lost language and social interactions.  Parents also report muted emotions.
Exposure Sources:  This infant was exposed to 100 mcg mercury the first six months of life via vaccines.  No dietary exposure from seafood or fish to the child.  Mother with 9 amalgam fillings and only occasional fish consumption during pregnancy.

Mercury Levels:  Hair analysis without mercury detection. Heavy metals challenge urine 8.6 mcg / g / creatine with a norm reference of 0-2.5 mcg/ g / creatine at 3 years 8 months of age. He is currently undergoing cyclic chelation therapy with oral DMSA.

Response To Treatment:  Parents report that his level of awareness, eye contact, emotions, and receptive and expressive language have all improved since starting the chelation program.

vedi:  AUTISMO + Autism REFERENCES + Autismo dai VACCINI + Autismo - La prova dei Danni dei Vaccini + Bibliografia su Autismo dai vaccini + Bibliografia Danni dei vaccini  +  Bibliografia danni 2  + Amish senza autismo perche' NON vaccinano + 1.000 studi sui Danni dei Vaccini  
 

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