|
INTRODUZIONE
Dal
1985 presso il Centro I.M.O. Sezione di Fisica dell’Università di Siena sono in
corso studi per lo sviluppo di una Biologia delle interazioni tra
biomolecole e campi elettrici e magnetici applicando metodi di
valutazione, che accanto a quelli tradizionali della biologia
(morfologici e funzionali) utilizza quelli propri della Fisica con
analisi fenomenologica, sia classica che semiclassica, e quantistica.
Uno degli argomenti trattati negli ultimi anni riguarda il rilevamento
degli effetti biologici prodotti da specifiche S.Q.M.E. applicate a
molecole biologiche complesse, a colture cellulari e a tessuti biologici
intatti. Sull’argomento esiste una vasta letteratura (oltre 25000
pubblicazioni) che riporta lavori, sia teorici che sperimentali,
riguardanti tra l’altro più di 8000 esperimenti su animali e 5000
sull’uomo, esperimenti eseguiti in innumerevoli laboratori
internazionali. L’analisi approfondita della grande quantità di dati
ha permesso l’individuazione, anche con elaborazioni originali, di
particolari S.Q.M.E. atte ad agire specificamente e selettivamente su
molecole (ad es. recettori di membrana) e su strutture.
I
risultati ottenuti cominciano a rendere ragione e a chiarire le molte
contraddizioni rilevate nei lavori riportati in letteratura. La fase
delle applicazioni e delle verifiche sperimentali è cominciata
all’inizio degli anni 90, dopo un lungo periodo di preparazione, con
la progettazione e la realizzazione presso il laboratorio del Dipartimento
di Fisica delle prime apparecchiature per la generazione delle
S.Q.M.E. Durante questa fase i dati sperimentali raccolti e le nuove
conoscenze hanno delineato i limiti della strumentazione utilizzata, per
cui sono state progettate e costruite, per una maggiore differenziazione
degli interventi, tre nuove apparecchiature, di cui una da laboratorio
per le applicazioni sulle colture cellulari e le altre due più grandi
per permettere le
applicazioni sull’uomo. Inoltre è stato definito un protocollo per
l’applicazione clinica che è stato sottoposto con esito positivo al
giudizio del Comitato
Bioetico Senese.
APPLICAZIONE
SPERIMENTALE
La
ricerca è proseguita sia sul fronte del trattamento di molecole e
colture di cellule cancerogene e normali presso il laboratorio del Centro
I.M.O. e sia con le applicazioni cliniche presso l’Istituto
di Anestesiologia e Rianimazione del Policlinico “Le Scotte” di
Siena conformemente al protocollo sperimentale approvato dal Comitato Bioetico Senese.
La
sperimentazione riguarda: l’azione selettiva su cellule tumorali
rispetto a quelle normali sia in vitro che in vivo,
il controllo del dolore, l’accelerazione della riparazione
tessutale anche in presenza di cellule tumorali, il controllodell’anafilassi
e dei fenomeni infiammatori, la riduzione delle metastasi ossee,
epatiche, cerebrali, ecc., e le sinergie positive con alcuni farmaci,
con le applicazioni radioterapiche e gli interventi chirurgici. Inoltre
tra i risultati più importanti raggiunti c’è il netto miglioramento
della qualità della vita qualunque sia lo stadio della malattia insieme
a un notevole allungamento del tempo di sopravvivenza anche nei casi più
estremi.
Per
soddisfare la sempre più crescente domanda di entrata nella
sperimentazione si prevede l’installazione di una terza macchina, già
in fase avanzata di realizzazione. La nuova unità operativa è stata
progettata tenendo conto delle precedenti esperienze e rende possibile
l’aumento del numero di azioni specifiche.
I
meccanismi d’azione disponibili diventano:
1)
-
distruzione di masse tumorali per intervento del sistema
immunitario attivato con le S.Q.M.E. dopo applicazione di piccole dosi
radioterapiche atte a mobilizzare antigeni di origine tumorale.
2)
-
Riduzione con specifiche S.Q.M.E. delle lesioni neoplastiche e
conseguente riduzione del dolore e miglioramento della qualità della
vita.
3)
-
Azione diretta di S.Q.M.E. specifiche sulle cellule tumorali con
progressiva riduzione della respirazione aerobica e conseguente aumento
di quella anaerobica fino all’esaurimento delle risorse interne di
energia seguita da apoptosi..
4)
-
Stimolazione dell’intero organismo con S.Q.M.E. specifiche per
il miglioramento della qualità della vita.
5)
-
Stimolazione con specifiche S.Q.M.E. dei fenomeni correlati alla
produzione e alla diffusione dei secondi messaggeri come ad esempio il
cAMP, l’IP3, il DAG, il Ca++ e altri.
6)
-
Controllo dell’anafilassi (azione sui recettori dei
mastociti)
e riduzione dei fenomeni infiammatori in generale con S.Q.M.E.
specifiche a soglia definita, in particolare intorno alle metastasi e
alle masse tumorali con riduzione dell’angiogenesi locale.
Per rendere sempre più precise le S.Q.M.E. da utilizzare nelle
applicazioni cliniche è in fase avanzata di sperimentazione il
prototipo di una apparecchiatura che determina i valori di alcuni
parametri strettamente legati al potenziale di membrana e alle
caratteristiche strutturali del paziente; valori che permettono
l’individualizzazione di specifiche S.Q.M.E. per azioni più mirate.
E’
inoltre in fase di completamento un prototipo di macchina
industrializzata che, oltre a fornire i campi e le modulazioni richieste
dalla sperimentazione, potrà permettere il controllo in linea e in
maniera continua e automatica dei principali parametri di azione e di
risposta per l’individuazione del protocollo definitivo di
applicazione.
Quanto
sopra è stato possibile grazie al contributo dell’Associazione
A.T.A.C.M.E. (Applicazioni Terapeutiche Antitumorali di Campi Magnetici
ed Elettrici) con in testa il suo presidente Cav. Luigi Bergomi.
Chiunque
desideri informazioni sulle applicazioni terapeutiche ai malati di
tumore o sullo stato della ricerca può richiederle tramite e-mail
all’indirizzo :
luigibergomi@tin.it
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
BIBLIOGRAFIA
su variazioni dei CEM e cellule
1.
BISTOLFI F., Campi magnetici in medicina,
Ed. Minerva Medica, Torino 1993
2.
FROHLICH H., KREMER F., (Eds), Coherent
excitation in biological systems, springer, 1983.
3.
SMITH C.W., BEST S., Electromagnetic Man,
J.M. Dent & Sonns, London, 1989.
4.
BARNOTHY M. F. Biological Effects of
magnetic Fields, Plenum Press, New York, 1969.
5.
LI K.H. Phiysical Basis of coherent
radiations from bio molecules, in: Proc. 1° Intl.
Symp. on photon Emission from Biological Systems,
Wroclaw, Poland, Ed. Jezowska-Trzebiatowska, pp.
63-95, 1987.
6.
BISTOLFI F. Radiazioni non ionizzanti,
ordine, disordine e biostruture, Ed. Minerva
Medica, Torino, 1989.
7.
COLLOT F. Valeur informationalle d’une
modulation. Information et interaction, Proceed.
Intern Symp. on Wave Therapeutics, Versailles, may
1979, pp. 32-42, Z. W. Wolkowski ed., Paris.
8.
RUBIK B. BEMS, Symposium explores
Mechanisms for ELF electromagnetic Bio effects,
Frontier Perspectives, 2 (2), pp. 1-24, 1991.
9.
POPP F.A., LI K.H., GU Q. Recent Advances
in Bio photon Research, World Scientific, 1992.
10.
POPP F.A.Photons, and their Importance to
Biology, Proceed. Intern Symp. on Wave
Therapeutics, Versailles, may 1979, pp. 43-59,
Z.W. Wolcowski ed., Paris.
11.
FROHLICH H. The extraordinary dialectric
properties of biological molecules and the action
of enzymes, Proc. Nat. Acad. Sci. USA, 72,
4211-15, 1975.
12.
FROHLICH H. Coherent excitation in active
biological systems. In: Modern Bio electro
chemistry, Gutman and Keyzer Ads., Plenua P.,
NewYork, pp. 241-261, 1986.
13.
LIU D.S., ASTUMIAN R.D., ISONG T.Y.
Activation of Na+ and K+ Pumping Modes of (Na-K)-ATPase
by an Oscillating Electric Field, The Journal of
Biological Chemistry, Vol. 265, No. 13, pp.
7260-7, 1990.
14.
TSONG T.Y. Deciphering the Language of
Cells, Trends in Bio chemical Sciences, 14, March
1989.
15.
POPP F.A. Electromagnetic control of cell
processes, Come in, 263, 60-94, 1980.
16.
GORGUN S. Arrest of the cellular
proliferation in neoplastic cells, Report of
experimental work of Univ. of Hannover, Dep.
Hematology and Oncology, Hannover, 1990.
17.
GORGUN S., UNSAC B. Clinical application of
electromagnetic fields for cancer treatment,
Report of Academic Commission of Numune Hospital,
Ankara, 1980.
18.
GORGUN S., BANKO E. In vitro control of the
cancer cell mitosis with the modulated
electromagnetic energy, National Cancer Institute,
Report in International Medical Congress, Sept.
1979.
19.
ADEY W. R. Frequency and power windowing in
tissue interaction with weak electromagnetic
fields, Proc. IEEE., 68, 1, pp. 119-25, 1980.
20.
ADEY W.R. Collective properties of cell
membranes. In: Interaction Mechanisms of low-level
Electromagnetic Fields in Living Systems, Norden
and Ramel eds., Royal Swedish Academy of Sciences,
Oxford Universty Press, pp. 47-77, 1989.
21.
ADEY W.R. ELF Magnetic Fields and Promotion
of Cancer: experimental studies. In Interaction
Mechanisms of Low-Level Electromagnetic Fields in
Living systems, Norden and Ramel eds., Royal
Swedish Academy of Sciences, Oxford Universty
Press, pp.23-46, 1989.
22.
ADEY W.R. Tissue interactions with non
ionising electromagnetic fields, Physiol. Rev.,
61, 435-514.
23.
DEL GIUDICE E., DOGLIA S., MILANI M.,
VITIELLO G. in Coherence in Biology and Response
to External Stimuli, H. Frohlich ed., Springer -
Verlag, Berlin, 1988.
24.
DEL GIUDICE E., DOGLIA S., MILANI M., SMITH
C.W., VITIELLO G. Magnetic flux quantization and
Josephson Behaviour in living systems, Physica
Scripta, Vol. 40, 786-791, 1989.
25.
DEL GIUDICE E. Coherence in condensed and
living matter, The Centre for Frontier Sciences,
Vol. 3, N°2, pp. 16-20, 1993.
26.
DEL GIUDICE E., PREPARATA G. Coherent
dynamics in water as a possible explanation of
biological membranes formation, Proceedings of the
Trieste Conference on the Origins of Life, Kluwer
Academic Press, in Press, 1994.
27.
WALLACH D.F.H. in: Biological membranes,
Vol. II, D. Chapman, D:F:N. Wallach eds., Acad.
Press, London, pp. 253, 1973.
28.
GUYTON A.C. Textbook of Medical Physiology,
W.B. Saunders Comp. Philadelphia, 1976.
29.
ERKOCAK, Genel Histoloji, DAG OKAN, Yay ltd.
sti., Istanbul, 1983.
30.
CIRELI, Genel Histoloji, Beta Bas. Yay. Dag.,
Istanbul, 1983.
31.
BURR H.S., NORTHROP F.S. The electro
dynamic Theory of Life, in: Quarterly Review of
Biology, N° 10, pp. 322,1935.
32.
BISTOLFI F. Radiazioni non ionizzanti,
ordine, disordine e biostrutture, Ed. Minerva
Medica, Cap. 6-9, Torino, 1989.
33.
AARHOLT E., FLINN E.A., SMITH C.W.
Biological effects of extremely low-frequency non
ionising radiation, Intl. Symp. RSI/CNFRS,
electromagnetic Waves and Biology, Jouyen-Josas,
Parigi, 1980.
34.
ASANOVA T.P., RAKOV A.I. The state of
health of persons working in electrical fields of
outdoor 400 and 500 KV switchyards, in:
G.Knickerbocker, Hygiene of labour and
Professional diseases, Vol.5, Special Publication
N° 10, Piscataway NJ: IEEE Power Engineering
Society, p. 1966. 1975.
35.
BACON H. The hazards on high-voltage power
lines, in: E. Goldsmith, N. Hildyard, Green
Britain or Industrial Wasteland. Oxford, Polity
Press, Basic Blackwell, 1986.
36.
COLEMAN M.,
BELL J., SKEET R. Leukemia incidence in
electrical
workers, Lancet, 2, 932-3.
37.
DELGADO J.M.R., LEAL J., MONTEAGUDO J.L.,
GRACIA M.C. Embriological changes induces by weak,
extremely low frequency electromagnetic fields, J.
of Anatomy, 134, 3, 533, 51, 1982.
38.
MCDOWALL. T.W: Leukemia mortality in
electrical workers in England and Wales, Lancet,
January 29, 246, 1983.
39.
SAVITZ D.A., CALLE E.E. Leukemia and
occupational exposure to electromagnetic fields:
review of epidemiological surveys, J. Occ. Med.,
29, 47-51, 1987.
40.
SAVITZ D.A. Childhood cancer and
electromagnetic field exposure, Am. J. Epidemiol.,
128, 21-38, 1988.
41.
WERTHEIMER N., LEEPER E. Adult cancer
related to electrical wires near the home, Int. J.
Epidemiol..,109, 273-84, 1982.
42.
WEWER R.A. Human circadian rhythms under
the influence of weak electric fields and the
different aspects of these studies, Intl. J.
Biometereology, 17(3), 227-32, 1973.
43.
AHLBOM A. et al., Biological effects of
power lines fields. New York State Power Lines
Project Scientific Advisory Panel Final Report.
New York S. Dept of Health, Corning Tower, Empire
State Plaza, Albany, 1987.
44.
LIN R.S. et al., Occupational exposure to
electromagnetic fields and the occurrence
of brain tumours, J. Occ. Med., 27, 413-19
1985.
45.
PERRY F.S. et al., Environmental
power-frequency magnetic fields and suicide,
Health Physics, 41, 267-77, 1981.
46.
WERTHEIMER N., LEEPER E. Magnetic field
ezposure rellated to cancer sub types, Ann. NY.
Acad. Sci., 502, 43-54, 1987.
47.
WILSON B. et al., Chronic exposure to ELF
fields may induce depression, Bio electro
magnetics, 9, 195-205, 1988.
48.
BARKER A.T., FOULDS I.S. Human skin battery
potentials, they variation with site, age and sex,
Clin. Phys. P., 4(11), 101-2, 1983.
49.
NORDENSTROM B.E.W. Biologically closed
electrical circuits: clinical, experimental and
theoretical evidence for an additional circulatory
system, Nordic Medical, Stockholm, 1983.
50.
POHL H. Natural oscillating fields of cells,
in: Coherent excitations in biological system,
FROHLICH H. and KREMER F. Eds., Springer-Verlag,
Heidelberg, 199-210, 1983.
51.
SMITH C.W. et. al., The emission of low
intensty electromagnetic radiation from multiple
allergy patients and other biological systems, in:
Proc. 1° Intl. Symp. on photon Emission from
Biological Systems, Wroclaw, Poland, January
24-24, Jezowska-Trzebiatowska et al. eds., 110-26,
1986.
52.
WAGENEDER F.M., GERMANN R.H. Electro
therapeutic Sleep and Electro anaesthesia, VERLAG
R.M., Graz, 1978.
53.
REID K. H. Mechanism of action of dental
electro-anaesthesia, Nature, 247, 150-1, 1974.
54.
BARR M. et. al., Photo dynamic therapy for
inoperable cesophageal, gastric and cholorectal
cancers, Abstracts issue Intern. Confer. on PDT
and Medical Laser Applications, Lasers in Medical
Sciences N° 39., London 19-21 July 1988.
55.
CHECCHUCCI A. Patologia da esposizione a
campi elettromagnetici: un’ipotesi di
inquadramento nosofrafico. In: Interaction of
Radiation with Matter, pp. 265-291, Ed. Scuola
Normale Superiore, Pisa, 1987.
56.
CHİABRERA. M. Grattorola, G.C. Parodi,
Stimulazione ellettromagnetica dell’osteogenezi
in: F. Bistolfi, ed., Campi magnetici in medicina,
Minerva Medica, 1986.
57.
DUBOURG G., COURTY G., PRIORE’ A.,
PAUTRIZIEL R. Stimulation des défences de l’organisme
par association d’un rayonnement electromagnètique
pulsè et d’un champ magnètique: tentative d’application
au traitement du cancer shez l’homme,
International Symposium on Wave Therapeutics, pp.
198-208, Versailles 19-20 maggio 1979, Ed. Z.W.
Wolkowski, 1979.
58.
HAIMOVICI N., LANGUASCO G.B. Campi
magnetici pulsati a bassa frequenza e debole
intensità nel trattamento delle affezioni e
arteriose degli arti in ortopedia a traumatologia,
In: BISTOLFI F. Campi magnetici in medicina, pp.
459-469, Ed. Minerva Medica, 1986.
59.
SZENT GYORGYI A. Bio electronics and cancer:
electronic desaturation of proteins in normal and
canceous tissues, Come in, 310, 109-113.
60.
BASSETT C.A.L. Medical benefits of electric
and magnetic fields. Electricity and magnetism in
biology and medicine. San Francisco Press Inc.,
USA, 1992.
61.
BASSETT C.A.L. Fundamental and practical
aspecs of therapeutic use of pulsed
electromagnetic fields, CRC Crir. Rew. Biomed. Eng.,
17, 451-259, 1989.
62.
BASSETT C.A.L.,. CARPENTER D.O. Therapeutic
use of electric and magneic fields in otrhopaedics,
In: CARPENTER D.O. ed., Biologic effects of
electric and magnetic fields, Academic Press, NY,
In press.
63.
BASSETT C.A.L. Physical and biological
principles affecting weak ELF electromagnetic bio
responses, in: C.T. Bringhton and S.R. Pollach Eds.,
Electromagnetics in biology and medicine, pp.
1-13, San Francisco Press, 1991.
64.
BRIGHTON C.T., PFEFFER G.B., POLLACK S.R.
In vivo growth plate stimulation in capacitively
coupled electric fields. J. Orthop. Res., 1-42,
1983.
65.
CANE V., BOT P., SOANA S. Effect of pulsed
magnetic fields on bone appositional growth rate
during the repair of transcorticals holes.
Electricity and magnetism in biology and medicine,
San Francisco Press, Inc. USA, 1992.
66.
CANE V., BOTTI P., FARNETI D., SOANA S.
Histomorphometric study of low frequency pulsing
electromagnetic fields on bone repair of
transcortical holes. Trans. BRAGS, 9, 19, 1989.
67.
CANE V., BOTTI P., FARNETI D., SOANA S.
Electromagnetic stimulation of bone repair. A
histomorphometric study, J. Orthop. Res., 9,
908-917, 1991.
68.
BECKER., C.A. BASSETT., BACHMAN C.H. Bio
electric factors controlling bone structure, in:
Bone bio dynamics. FROST H. ed., Little Brown and
Co., Boston, 1964.
69.
MIR L.M., ORLOWSKI S., BELEHRADEK J.,
PODDEVIN JR B., PRON S., DOMENGE C., BELEHRADEK
M., LUBOINSKI B., PAOLETTI C. Electro chemio
therapy: A new anti tumour treatment using
electric pulses. Institute Gustave Roussy,
Villejuif, France. Electricity and magnetism in
biology and medicine. San Francisco Press, Inc.,
USA, 1992.
70.
PILLA A.A. State of the art in
electromagnetic therapeutics. Electricity and
magnetism in biology and medicine. San Francisco.
Press, Inc., USA, 1992.
71.
PILLA A.A., FIGUEIREDO M., NASSER P.R.,
KAUFMAN J., SIFFERT R.S. Broadband EMF
acceleration of bone repair in a rabbit model is
independent of magnetic component. Electricity and
Magnetism in biology and medicine. San Francisco
Press, Inc., USA, 1992.
72.
PLIQUETT F. PLIQUETT. Pulse impedance
measurements. Their applications in medicine and
research. Electricity and Magnetism in biology and
medicine. San Francisco Press, Inc., USA, 1992.
73.
RYABY J.T., MAGEE F.P., MEINSTEIN A. The
effect of combined AC/DC magnetic fields on
resting articular cartilage metabolism.
Electricity and magnetism in biology and medicine.
San Francisco Press, Inc., USA, 1992.
74.
SISKEN B.F., WALKER J. Nerve regeneration,
implication for clinical applications of
electrical stimulation. Electricity and Magnetism
in biology and medicine. San Francisco Press, Inc,
USA, 1992.
75.
WALLECZEK J., MILLER P., ADEY W.R.
Simultaneous dual-sample fluorimetric detection of
real-time effects of ELF electromagnetic fields on
cytosolic free calcium and divalentcation flux in
human leukemic T-cells(Jurkat). Electricity and
Magnetism in biology and medicine. San Francisco
Press, Inc., USA, 1992.
76.
BISTOLFI F. Campi magnetici in medicina, p.
363, Ed. Minerva Medica, 1983.
77.
FREEMAN N. Biological and clinical effects
of low frequency electric and magnetic fields,
Australas. Phys. & Engl. Sci. Med., 3.
182-192, 1980.
78.
HAIMOVICI N. Quattro anni di esperienza con
terapia con campi magnetici pulsanti a bassa
frequenza in ortopedia e traumatologia, Atti del
II Congresso Int. Magnetomedicina, Roma 1980.
79.
BISTOLFI F. Campi magnetici in medicina, p.
364, Ed. Minerva Medica, 1983.
80.
GIUBBOTTI A. Effetto dei campi magnetici
pulsanti sulla flogosi dei seni parasanali, Atti
del II Congr. Int. di Magnetomedicina, Roma, 1980.
81.
BISTOLFI F. Campi magnetici in medicina,
pp. 365, Ed. Minerva Medica, 1983.
82.
ROSSANO C. La
magnetoterapia ad impulsi nel dolore erpetico e
post-erpetico, Clinica Europea, XXII, 6,
novembre-dicembre, 1983.
83.
MUSTACCHI G. Trattamento di sindromi
dolorose neoplastiche con magnetoterapia ronefor,
Atti VI Cong. Naz. dell’Ass. It per lo studio
del dolore, Trieste, maggio 1982.
84.
NEUMANN E. Membrane electroporation: toward
a molecular mechanism, Univ. Of Bielefeld, Germany.
Electricity and magnetism in biology and medicine.
San Francisco Press, Inc, USA, 1992.
85.
MOUNEIMNE Y. Electroinsertion
of proteins into membranes: a novel approach to
the study of membrane receptors, Harvard Univ.
Usa. Electricity and magnetism in biology and
medicine. San Francisco Press, Inc., USA, 1992
86.
BISTOLFI F. Radiazioni non ionizzanti,
ordine, disordine e biostrutture, pp. 209-246,
Minerva Medica, Torino, 1989.
87.
BISTOLFI F. Campi magnetici in medicina,
pp. 384, Ed. Minerva Medica, 1983.
88.
MICLAVCIC D., REBERSEK S., SERSA G.,
NOVAKOVIC S. Nonthermal anti tumour effect of
electrical direct current on murine fibrosarcoma
SA-1 tumour model, in: Electromagnetics in Biology
and Medicine, C.T. Bringhto GRUNDLER W., KAISER F.
Mechanics of Electromagnetic Interaction with
Cellular Systems, Naturwissenschaften, 79, 551-
559, 1992.n and S.R. Pollack eds, San Francisco
Press Inc, San Francisco, Ca-USA, 1991
89.
ADEY W.R. Whispering Between Cells:
Electromagnetic Fields and Regulatory Mechanism in
tissue, Frontier Perspectives, Vol. 3, N°2, Fall,
1993.
90.
GRUNDLER W., KAISER F. Mechanics of
Electromagnetic Interaction with Cellular Systems,
Naturwissenschaften, 79, 551- 559, 1992.
91.
JOSEPHSON B.D. PHYS. IETT., 1, 251, 1962.
92.
BOX G.E.P., HUNTER W.G., HUNTER J.S.
Statistics for experiments, New York, 1978.
93.
FLETCHER R. Practical methods of
optimisation, John Wiley & Sons, New York,
1987.
94.
ADEY W. Ross. Electromagnetics in biology
and medicine in: Modern Radio Science edited by
Hiroshi matsumoto, pp. 231-249, 1993.
95.
TSONG T.Y. Deciphering the language of
cells, Trends in Biochemical Sciences, Vol. 14,
pp. 89-92, 1989.
96.
SIENKIEWICZ Z.J., CRIDLAND N.A., KOWALCZUK
C.I. and SAUNDERS R.D. Biological effects of
electromagnetic fields and radiation in: The
Rewiew of Radio Science 1990-1992, edited by M.
Ross Stone, pp. 737-770, 1993.
97.
TENFORDE T.S. Cellular and molecular
pathways of extremely low frequency
electromagnetic field interactions with living
systems in: Electricity and Magnetism in Biology
and Medicine, edited by Martin Blank, pp. 1-8,
1993.
98.
HAND J.W. and CADOSSI R. Therapeutic
applications of electromagnetic field in: The
rewiew of Radio Science 1990-1992, edited by
W.Ross Stone, pp. 779-796, 1993.
99.
PILLA A.A.. State of the art in
electromagnetic therapeutics in: Electricity and
Magnetism in Biology and Medicine, Edited by
Martin Blank, pp. 17-22, 1993.
100.
HILLE B. Ionic channels of excitable
membranes, Sinour Asociates Inc., Masschusetts,
1984.
101.
CLEARY S.T. Biophysical mechanisms of
interaction in: The rewiew of Radio Science
1990-1992, edited by W.Ross Stone, pp. 717-735,
1993.
102.
PILLA A.A., NASSER P.R., KAUFMA J.J. Gup
junction impedance, tissue dielectrics and thermal
noise limits for electromagnetic field bioeffects.,
Bioelectrochemistry Lab., Department of
Orthopaedics, Mount Sinai School of Medicine, New
York., In: Bioelectrochemistry and Bioenergetics,
35, pp. 63-69, 1994.
103.
TENFORDE T.S. Health effects of
low-frequency electric and magnetic fields,
Environ. Sci.
104.
TRAICOV L.L., KUZMANOVA M.A., IVANOV S.P.
and MARCOV M.S. Effect of static magnetic field on
lectin binding to erythrocyte membrane,
Bioelectrochemistry and Bioenergetics, Vol. 35,
pp. 49-52, 1994.
105.
CIESLAR G., SIERON A., TURCZYNSKI B.,
ADAMEK M. and JASKOLSKI F. The influence of
extremely low-frequency variable magnetic fields
on rheologic and dielectric properties of blood
and the water-electrolyte balance in experimental
animals, Bioelectrochemistry and Bioenergetics,
Vol.35, pp. 29-32, 1994.
106.
LIU D.S., ASTUMIAN R.D., TSONG T.Y.
Activation of Na+ and K+ Pumping Modes of (Na,K)
ATPase by an Oscillating Electric Field., Printed
in USA. The Journal of Biological Chemistry., Vol.
265, N°13, Issue of May 5, pp. 7260-7267, 1990.
107.
SERSA G. (a), CEMAZAR M.(a), MICLAVCIC D.
(b), MIR M. Lluis. (c)., Electrochemoterapy:
variable anti-tumour effect on different tumour
models., (a) Institute of Oncology, Dep.of Tumour
Biology, Ljubljana, Slovenia.,(b) Univ. of
Ljubljana, Faculty of Electrical and Computer
Engineering, Ljubljana, Slonenia., (c) Department
of Antitumour Pharmacology, Institut
Gustave-Roussy,, Villejuif, France.
Bioelectrochemistry and Bioenergetics 35, pp.
23-27, 1994.
108.
MIR M.L., ORLOWSKI S., BELEHRADEK Jr. J.,
PODDEVIN B., PRON G., DOMENGE C., BELEHRADEK M.,
LUBOINSKI B., PAOLETT C. Electrochemotherapy: A
new antitumour treatment using electric pulses,
Institut Gustave-Roussy, Villejuif, France. In:
Martin Blank, Ed., Electricity and Magnetism in
Biology and Medicine, San Francisco Press, Inc.,pp.
119-121, 1993.
109.
DEL GIUDICE E., DOGLIA S., MILANI M., SMITH
C.W. and VITIELLO G. Magnetic flux quantization
and Josephson behavior in living systems, Physica
Scripta, Vol. 40, pp. 786-791, 1989.
110.
GORDON PETERS. Cell cycle stifled by
inhibitions, News and Views, Nature., Vol. 371,pp.
204-260., 15 September 1994.
111.
ADEY W.R. Electromagnetic fields, cell
membrane amplification and cancer promotion,
Extremely Low Frequency Electromagnetic Fields:
The question of cancer, Wilson, B. W. Stevens,
R.G., and Anderson, L.E., eds, Columbus, Ohio,
Battelle Press, 211-250, 1990.,(b)*
112.
BENTAL R.H.C. Low-level pulsed
radiofrequency fields and the treatment of
soft-tissue injuries, Bioelectrochem.
Bioenergetics, 16, 531-548, 1986.
113.
BLANK M. “Na,K-ATPase function in
alternating electric fields”, FASEB J., 6, pp.
2434-2438, 1992.
114.
BLANK M., SOO L. “Ion activation of the
Na,K-ATPase in alternating currents”.
Bioelectroche. Bioenerget., 24, pp. 51-61, 1990.
115.
ALBERTINI A., NOERA G., PIERANGELI A.,
ZUCCHINI P., CADOSSI R. Effects of low-frequency
pulsedd electromagnetic fields on experimental
myocardial infarcts in rats., in C.T. Brington and
S.R. Pollack. Eds. Electromagnetics in Medicine
and Biology, San Francisco Press, pp. 187--190,
1991.
116.
BRINGTON C.T. Advanced clinical
applications of electromagnetic field effects bone
and cartilage, in C.T. Brington and S.R. Pollack.,
Eds. Electromagnetics in Medicine and Biology, San
Francisco, San Francisco Press, pp. 293-308, 1991.
117.
PILLA A.A., NASSER P.R., KAUFMAN J.J., in
ALLEN M.J., CLEARY.F., SOWERS A.E., SHILLADY D.D.
Eds, Charge and Field Effects in Biosystems, 3,
Boston: Birkhauser, pp. 231-241, 1992.
118.
TRAICOV L.L., (a) CUZMANOVA M.A.,(a) IVANOV
S.P., (a) MARCOV M.S.,(b) Effects of static
magnetic fields on lectin binding to erythrocyte
membrane, (a) Department of Biophysics and
Radiobiology, Sofia Univ. Bulgaria.,(b)
Bioelectrochemistry Lab. Mount Sinai Medical
Center, New York, USA. In: Bioelectrochemistry and
Bioenergetics, 35, pp. 49-52, 1994.
119.
LEW V.L., BEAUGE L. In membrane Transport
in Biology (Giebisch G.,TOSTESON D.G., USSING H.H.
Eds.), pp. 81-115, Springer-Verlag,
Berlin-Heidelberg, 1979.
120.
BELEHRADEK Jr.J., ORLOWSKI S., PODDEVIN B.,
PAOLETTI C., MIR L.M. Electrochemotherapy of
spontaneous mammary tumours in mice, Eur. J.
Cancer 27: 73-76, 1991.
121.
DEL GIUDICE E., DOGLIA S., MILANI M.,
VITIELLO G. Nucl. Phys. 251B (FS13), 375 (1985),
Nucl. Phys. 275B, (FS17), 185 (1986); Frohlich H.,(Ed),
Structures, correlations and electromagnetic
interactions in Living matter: theory and
applications. In: Biological Coherence and
Responce to External Stimuli, p.49, Springer
(1988).
122.
De LATEUR B.J., LEHMANN J.F., STONEBRIDGE
J.B., WARREN C.G., GUY A.W. Muscle heating in
human subjects with 915 Mhz. Microwave contact
applicator. Arch. Phys.Med. 51, 147, 1970.
123.
MCAFEE R. D. Analeptic effect of microwave
irradiation on experimental animals. IEEE Trans,
Microwave theory techniques. Vol. MTT 19, 251,
1971.
124.
NADASDI M. Inhibition of experimental
arthritis by athermic pulsating short waves in
rats. Orthopedics 2, 1960.
125.
ATALAY Muzaffer.: Clinical results of the
treatment of cancer with modulated EM energy, on
the terminal cancer patients, according to the
“Method of GORGUN”. Seminary, 1979.
126.
GUNER Z., KAYABALI I.: Experimental
research work on Electrotherapeutic sleep and
Electroanesthesia. Surgical team: KAYABALI I.,
GORGUN S., TUGCU K., DUMAN H., NUMANOGLU H., 1970.
127.
GORGUN S. and Coll.: Experimental research
work on cell membrane and the control of the cell
mitosis with the modulated EM energy, according to
the “Method of GORGUN”. Sea Biology Lab.,
1972-1973.
128.
GORGUN S., OZCELIK F.: Control of the
cancer cell mitosis with the modulated EM energy,
according to the “Method of GORGUN “, on white
mice. Institute for Biophysics and Nuclear
Medicine, 1974.
129.
GORGUN S., OZCELIK F.: experimental
research work on regeneration of the medulla
spinalis with the modulated EM energy, according
to the “Method of GORGUN”, after experimental
injury on animals. 1974.
130.
GORGUN S., OZCELIK F., GURMAN I.:
Demostration on the cancer cell culture (for
control of the cell mitosis) with the modulated EM
energy, according to the “Methot of GORGUN”.
Faculty of science, Nuclear research centre. 1975.
131.
GORGUN S.: Study on the effects of the
modulated EM energy on the infected tissue,
according to the “Methot of GORGUN”. 1976.
132.
GORGUN S., BANKO E.: Experimental invitro
work on, control of the cancer cell mitosis with
the effect of modulated EM energy, according to
the “Methot of GORGUN”. Nationale Cancer
Institute, Research Division, 1979.
133.
GORGUN S. BANKO E.: Control of cancer cell
membrane functions with the modulated EM energy,
according to the “Method of GORGUN”. Staff
Conference. National Cancer Institute, Research
Division. 1979.
134.
GORGUN S.: Treatment of cancer with the
modulated EM energy, according to the “Method of
GORGUN”. on the terminal cancer patients. Pub.
Scientific Research Center. 1980.
135.
GORGUN S. De RENZO A.: Clinical
applications of symptomatic cancer treatment with
modulated EM energy, on the terminal cancer
patients, according to the “Method of GORGUN”.
1985.
136.
GORGUN S. De RENZO A.: Clinical
applications of symptomatic cancer treatment with
modulated EM energy, on the terminal cancer
patients, according to the “Method of GORGUN”.
Staff Conf., Dec. 1985.
137.
GORGUN S. De RENZO A.: Clinical
applications of the treatment of cancer with the
modulated EM energy, according to the “Method of
GORGUN”, on the terminal cancer patients.
1988-1991.
138.
GORGUN S. De RENZO A.: Clinical
applications of the treatment of cancer with the
modulated EM energy, according to the “Method of
GORGUN”, on the terminal cancer patients.
International Seminary, Patologia specifica delle
ELF. 1991.
139.
GORGUN S. De RENZO A.: Possibilità di
trattamento del cancro con energia
elettromagnetica. Libera Università Trapani, Anno
X - N.29 Novembre 1991. (Clinical applications of
the treatment of cancer with the modulated EM
energy, according to the “Method of GORGUN”,
on the terminal cancer patients).
140.
GOODMAN R. and HENDERSON A.S:
Transcriptions and translations in cells exposed
to extremely low frequency electromagnetic fields,
Bioelectrochem. Bioenerget. 25: 335-355, 1991.
141.
ITO H., BASSETT C.A.,L.: Effect of weak
pulsing electromagnetic fields on neural
regeneration in the rat, clinical orthop. and
related research 181:283-290, 1983.
142.
KADIOGLU Y.: Clinical applications and
results of the treatment of cancer with modulated
EM energy, on the terminal cancer patients,
according to the “Method of GORGUN”. Seminary,
1979.
143.
KANJE M., RUSOVAN A., SISKEN B.F., LUNDBORG
G.; Pretreatment of rats with pulsed
electromagnetic fields enhance regeneration of the
rat sciatic nerve. Bioelectromagnetics (in press).
144.
KAYABALI I.: Personal Communications for
the control of cancer cell membrane functions, in
vitro, with the effect of modulated EM energy,
according to the “Method of GORGUN”.
1970-1973.
145.
KAYABALI I.: Personal Communications for
the control of cancer cell membrane functions, in
vitro in vivo with the effect of modulated EM
energy, according to the “Method of GORGUN”.
1974-1975.
146.
KAYABALI I.; Personal Communications for
the clinical results of the treatment of cancer
with modulated EM energy, on the terminal cancer
patients, according to the “Method of GORGUN”.
1979.
147.
KERNS J.M., FAKHOURI A.J., WEINRIB H.P.,
FREEMAN J.A.: Electrical stimulation of the nerve
regeneration in the rat. Neuroscience 40:93-107,
1991.
148.
ORGEL M.G., O’BRIEN W.J., MURRAY H. M.,
Pulsing electromagnetic field therapy in nerve
regeneration. An experimental study in the cat,
Plast. reconstr. surg. 73:173-183, 1984.
149.
OSBORN K. D., TRIPPEL S. B., MANKIN H. J.:
Growth factor stimulation of adult articular
cartilage. J. Orthop. Res. 7:35, 1989.
150.
PILLA A.A., FIGUEIREDO M., NASSER P.R.,
KAUFMAN J. J., SIFFERT R.S.,: Broadband EMF
acceleration of bone repair in a rabbit model is
independent of magnetic component. Electricity and
magnetism in biology and medicine. San Francisco
Press, Inc. 1992. U.S.A.
151.
PLIQUETT U., PLIQUET F.: Pulse impedance
measurements. Their application in medicine and
research. Electricity and magnetism in biology and
medicine. San Francisco Press, Inc. 1992. U.S.A.
152.
RYABY J.T., MAGE F.P., WEINSTEIN A.M.: The
effect of combined AC/DC magnetic fields on
resting articular cartilage metabolism.
Electricity and magnetism in biology and medicine.
San Francisco Press, Inc. 1992. U.S.A.
153.
RUSOVAN A., KANJE M.: Stimulation of
regeneration of the rat sciatic nerve by 50 Hz.
sinusoidal magnetic fields. Exp. neurol.
112:312-316, 1991.
154.
SAMARAS G.M., MURAFF L.R., ANDERSON G.E.:
Prolongation of life during high intensity
microwave exposures. IEEE trans Vol. MTT 19, 245,
1971.
155.
SIEERA R. C., HALTER S., TANNER J.A.:
Effect of an electromagnetic field on the process
of wound healing. Dept. of anatomy, Queen
University, Third int. Symposium, Varna, Vol. 33,
10, 1967.
156.
SINAV M.: Clinical results of the treatment
of cancer with modulated EM energy, on the
terminal cancer patients, according to the
“Method of GORGUN”. Seminary, 1979.
157.
SISKEN B.F., WALKER J.: Nerve regeneration,
implications for clinical applications of
electrical stimulation. Electricity and magnetism
in biology and medicine. San Francisco Press, Inc.
1992. U.S.A.
158.
SISKEN B.F.:Electric and pulsed
electromagnetic field effect on nerve tissue
regeneration, in C.T. Brighton and S.R. Pollack,
Eds., Electromagnetics in medicine and biology,
San Francisco Press, 1991, 259-274.
159.
SISKEN B.F., KANJE M., LUNDBORG G., HERBST
E., KURTZ W.: Stimulation of rat sciatic nerve
regeneration with pulsed electromagnetic fields.
Brain. res. 485:309-316, 1989.
160.
TEMUCIN T.: Clinical applications and
results of the treatment of cancer with modulated
EM energy, on the terminal cancer patients,
according to the “Method of GORGUN”. Seminary,
1979.
161.
WHEELER P. C., WHEELER M.C.:
Electromagnetic wound healing; Further clinical
and basic considerations. Dept. of Phys. Medicine
and rehabilitation, University of Missouri Medical
center. Third int. Symposium, Varna. Vol. 33, 10,
1967.
162.
WORDEN R., HERRIK J., WAKIM, KRUSEN F.: The
heating effects of microwaves with and without
ischaemia. Arch. Phys. Med. 29, 751, 1948.
163.
YALCIN S.: Clinical applications and
results of the treatment of cancer with modulated
EM energy, on the terminal cancer patients,
according to the “Method of GORGUN”. Seminary,
1979.
164.
ZIENOWICZ R.J., THOMAS B. A., KURTZ W.H.,
ORGEL M.G.: A multivariate approach to the
treatment of peripherial nerve transection injury.
The role of electromagnetic field therapy. Plast.
reconstr. surg. 87:122-129, 1991.
165.
ZIMMER R.P., ECKER H.A., POPOVIC V.P.:
Selective electromagnetic heating of tumours in
animals in deep hypothermia. IEEE trans. on
microwave theory techniques, Vol. MTT 19, 238,
1971.
Pag.2
|
"Questo sito
WEB vi informa"
Non siamo
responsabili della correttezza e/o della solvibilità
degli inserzionisti del ns. Network
Webmaster
- Copyright © 1998, Publisher Bamico ltd - All rights reserved
Tutti i diritti riservati - Vietata
la copia anche parziale dei contenuti, se non viene citata la fonte |
|
|
