COLLEGAMENTO fra CANDIDA e CANCRO 
(LINKS between CANCER and Candidiasis)
E' INDISPENSABILE per stare sempre BENE e' l'assunzione quotidiana, per certi periodi,
di acqua Basica a pH min. di 7,35 > 11 (almeno 1,5 lt)
Le bevande troppo saline e/o le bevande industriali, non vanno bevute giornalmente e/o spesso,
anche e per le loro forti acidita', in quanto influiscono sull'alterazione dei giusti valori di pH dell'acqua del corpo.
L'acidosi e' la base fisiologica del Cancro -  Il Conflitto Spirituale Irrisolto, ne e' la Causa primaria
Nutriterapia Biologica Metabolica x Cancro
  Circolazione sanguigna: prevenzione degli infarti e del cancro. I citrati eliminano calcificazioni arteriose. Gli ascorbati fanno il resto !
Paolo-Lissoni: i-segreti-della-pineale-anticancro-io-oncologo-vi-spiego-perche-la-medicina-esclude-di-bella/
 

Visionare questa intervista:
http://www.curenaturalicancro.org/base_schermo_grande_testimonianza_dottore.htm

Diagnosi precoce di tutte le malattie importanti, specie quelle degenerative, tipo il Cancro
Per difendere la tua vita e quella dei tuoi cari, basta poco.
E ' confermato che il test dell'acido tiodiglicolico nelle urine si può eseguire dal giorno 15 settembre a Palermo presso il Policlinico di Palermo dell’Università degli Studi:  091.6553167 al costo di € 40
Bergamo: Radical Service - Tel.: 035.4821033 - Fax: 035.4821033
(L'acido tiodiglicolico è un prodotto fisiologico del metabolismo umano. Un innalzamento dei livelli urinari di tale metabolita sono un indice dello squilibrio dell'attività ossido-riduduttiva della cellula (stress ossidativo).
L'acido tiodiglicolico si forma da diversi pathway metabolici: ad esempio è coinvolto nel pathway ossidativo della creatina che coinvolge le vitamine B2, B6, il tetraidrofolato, il glutatione e l'urea).

Non è un test di condanna a morte, ma un test preventivo, una prevenzione per monitorare tutto il sistema antiossidante.
Questo permetterà di evitare che l'organismo possa andare in stress ossidativo e quindi in patologia degenerativa.
E' consigliato principalmente a tutte le persone anziane, e prima di fare qualsiasi vaccino;
A tutte le persone che hanno problemi cardiaci e problemi all'apparato digerente. Tutte le persone che hanno vissuto e vivono in ambienti inquinati.
Se l'esame risulta positivo (presenza della molecola) il dato va trasmesso per ora alla Associazione per la ricerca scientifica "emmanuele": e- mail emmanuele.ars@hotmail.it  che gratuitamente ti indicherà una terapia integrante per eliminare la causa.
In tutti i casi riusciamo sempre a tirare fuori la gente da questa situazione.
Perchè Palermo e Bergamo soltanto ? perche' vi sono resistenze da parte degli enti ufficiali, affinche' non si cambino gli attuali protocolli del Ministero della "sanita' ", che e' legato a filo doppio con Big Pharma...
Questa mia scoperta e del 1998 (relazione scientifica firmata da tanti scienziati e da direttori di compartimento dell'Università di Palermo) osteggiata da tutti per i motivi che potete immaginare. Ci vorrà molto tempo per divulgarla e farla applicare ovunque.

La Seria RICERCA sul CANCRO (ostacolata dall'Oncologia ufficiale)  - vedi anche: Ascorbato di Potassio

Commento NdR: anche se rispettiamo ed indichiamo in questo portale, tutte le possibili terapie naturali per ogni malattia, anche perche' le reazioni ad ogni tipo di terapia sono diverse da soggetto a soggetto, vogliamo ricordare che anche il cancro come qualsiasi altra malattia nasce in "luoghi" ben precisi e quindi ogni malattia ha le sue Cause, con Cause secondarie e terziarie.

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How A Benign Fungus Can Become Life-Threatening
Researchers at the Agency for Science, Technology and Research’s Institute of Molecular and Cell Biology have discovered new molecular mechanisms that provide a more detailed understanding of how the normally benign Dr. Jekyll-like fungus known as Candida Albicans transforms into a serious and often life-threatening Mr. Hyde-like form.

C. Albicans can cause serious and potentially life-threatening infections in the mouth, blood and other tissues of people who are undergoing cancer chemotherapy or radiation treatments, or who have developed AIDS or other diseases that damage the immunity of the individual.

In two separate papers recently published in Developmental Cell and the EMBO journal, the team of scientists led by Wang Yue, principal investigator at IMCB, have managed to reveal previously unknown mechanisms which are responsible for causing the infectious phase of C. Albicans.

The fungus starts its ‘attack’ on a patient by changing its oval shape into a filamentous form, which has thin, threadlike appendages emerging from the cell body. Wang’s team, who has been studying C. Albicans for more than seven years, was responsible for identifying the master “controller” protein called Hgc1 in 2004.

This “controller” functions like a regulator and tells the fungus when to start the transformation from the harmless oval shape to the infectious filamentous form.

“One question remained, however - how does it activate the cellular machineries that determine the fungal cell shape?” said Wang.

Wang’s team found the answer to this question in two proteins called Rga2 and Cdc11. They discovered that they each function like a switch on two different cellular machineries that normally determines cell shape. “The master regulator Hgc1 acts like the ‘finger’ that flips the switches to start the infection process,” said Wang.

“Our findings have uncovered detailed molecular mechanisms which define how these two proteins interact with the master ‘controller’ to cause infections. This has opened new opportunities for us to investigate further into a new range of therapeutic targets for fungal infections,” explained Wang.

In the same issue of Developmental Cell, the team’s work was given an expert mention by a leading C. Albicans researcher, Dr. Peter Sudbery, stating its importance in bringing awareness of the cellular processes that is necessary for C. Albicans to transform to its infectious state.

In addition, the new knowledge of the detailed interaction of these proteins with other cellular machineries has also revealed critical information on how cells in general determine their shape, a fundamental question in biology as Rga2 and Cdc11 are also found in nearly all eukaryotic organisms.

Largely due to the AIDS pandemic in the last 25 years, the once nearly harmless and commensal fungus Candida Albicans has become one of the most prevalent microbial pathogens in AIDS patients, causing life-threatening infections with high death rate, especially in infected children.

References: XD Zheng, RTH Lee, YM Wang, QS Lin, and Y Wang. Phosphorylation of Rga2, a Cdc42 GAP, by CDK/Hgc1 is crucial for Candida Albicans hyphal growth. The EMBO Journal 26, 3760-3769 (2007).

I Sinha, YM Wang, R Philp, CR Li, WH Yap, and Y Wang Cyclin-Dependent Kinases Control Septin Phosphorylation in Candida Albicans Hyphal Development. Developmental Cell 13: 421-432 (2007).
Tratto da: http://www.sciencedaily.com/releases/2007/10/071004165553.htm

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University of Genova and National Institute for Cancer Research, Italy  - viscolic@unige.it
In a surveillance study of candidemia in cancer patients that was conducted by the European Organization for Research and Treatment of Cancer, 249 episodes were noted;
Candida Albicans was isolated in 70% (63) of the 90 cases involving patients with solid tumors (tumor patients) and  in 36% (58) of the 159 involving those with hematologic disease (hematology patients). Neutropenia in tumor patients and acute leukemia and antifungal prophylaxis in hematology patients were significantly associated with non-Albicans candidemia in a multivariate analysis.
Overall 30-day mortality was 39% (97 of 249). In a univariate analysis, Candida glabrata was associated with the highest mortality rate (odds ratio, 2.66). Two multivariate analyses showed that mortality was associated with older age and severity of the underlying disease. Among hematology patients, additional factors associated with mortality were allogeneic bone marrow transplantation, septic shock, and lack of antifungal prophylaxis.
 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=99379706

Commento (NdR): Finalmente si iniziano a ricercare le Vere conCause del cancro; ma gli Oncologi ufficiali Allopati non hanno ancora capito che i funghi, come certi altri batteri (Sarcina ventriculi) + le intossicazioni e le infiammazioni, sono corresponsabili della nascita del Tumore nei tessuti degli organi bersaglio del Conflitto Spirituale.

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Lavori Pubblicati (in inglese) sull’associazione Candida/Tumore
Med. Pediatr. Oncol. 1999 May;32(5):344-8 Fungal colonization and infection in children with acute leukemia and lymphoma during induction therapy.
Gozdasoglu S, Ertem M, Buyukkececi Z, Yavuzdemir S, Bengisun S, Ozenci H, Tacyildiz N, Unal E, Yavuz G, Deda G, Aysev DPediatric Hematology-Oncology Research Center, Ankara University School of Medicine, Dikimevi, Turkey. BACKGROUND: Fungal infection represents a growing problem in children with hematologic malignancies. During chemotherapy induced neutropenia, colonization with fungi is considered a major risk factor for subsequent fungal infection. The rates and risk factors for mycotic infections in pediatric oncology patients is undetermined, particularly for centers in developing countries. The aim of this study was to evaluate the rates and risk factors of fungal colonization in children with acute leukemia and lymphoma at one of the major pediatric hematology/oncology centers in Turkey.
PROCEDURE: Fifty-two consecutive children newly diagnosed with acute leukemia and lymphoma during intensive remission induction therapy were evaluated for the occurrence of fungal colonization (defined as at least one positive surveillance culture) and infection.
RESULTS: Thirty-six of the 52 patients (69.2%) were colonized by Candida Albicans which was the only fungus isolated from surveillance cultures. There were three (5.8%) proven systemic fungal infections: two cases of candidemia and one case of brain abscess with Aspergillus spp. isolated from tissue. All patients with fungal colonization were receiving prophylactic or curative antibiotics. No significant association was found between type of disease and fungal colonization, but there was a significant association with neutropenia.
CONCLUSIONS: Our findings suggest that there is a high rate of fungal colonization in children receiving remission induction therapy for acute leukemia and lymphoma. Limiting the use of antibiotics and instituting antifungal chemoprophylaxis may decrease the rate, while the early initiation of empiric antifungal therapy in patients with fever and suspected mycotic colonization may increase survival in these patients.
Carcinogenesis, Vol 13, 783-786, Copyright © 1992 by Oxford University Press (PRIVATE ARTICLES)

Candida Albicans as a promoter of oral mucosal neoplasia
JF O'Grady and PC Reade, Section of Oral Medicine and Oral Surgery, School of Dental Science, University of Melbourne, Victoria, Australia.
A model of oral mucosal carcinogenesis using the water-soluble carcinogen 4-nitroquinoline-1-oxide (4NQO) was combined with a model of oral mucosal candidosis to examine the ability of Candida Albicans to promote the development of neoplasia in suitably initiated epithelium. Sprague-Dawley rats were initiated by the application of 4NQO to their palatal and tongue mucosa 3 times weekly for 4 weeks. The animals then received either application of a phorbol ester to act as a promoter, induction of experimental oral mucosal infection with C. Albicans, or no further procedures. Animals were killed at 34 or 52 weeks and the tongues and palates sectioned for light-microscopic examination. Control groups with no treatment, mucosal infection only, phorbol ester application only, 4NQO with the tetracycline or vehicle application only were also used.
The development of carcinoma in the experimental groups was similar to that in the positive control groups, indicating that the particular strain of Candida used had a similar ability to promote neoplastic changes as the known promoter phorbol-12,13- didecanoate and caused neoplastic changes to occur by week 34 with no additional lesions occurring by week 52. This indicated that the speculation that strains of C. Albicans may participate in causing neoplastic transformation in humans was well founded.
Copyright © 1992 by Oxford University Press.

Indian J Gastroenterol 1989 Jul;8(3):171-2
Association of Candida with carcinoma of esophagus.
Bhatia V, Kochhar R, Talwar P, Gupta NM, Mehta SK
Twenty-five patients with carcinoma of the esophagus (group I) and 25 patients suffering from non-ulcer dyspepsia with normal endoscopy (group II) were studied to know the incidence of isolation of Candida from their esophagus. Endoscopic brushings were taken from the esophagus in both groups and studied by smear examination and culture. Fungal organisms could be detected in 75% of cases of group I and 32% of cases of group II by culture techniques, and 45.8% and 12% respectively by smear examination. The difference was statistically significant (p less than 0.05) for both the techniques. Candida Albicans was the commonest species isolated. No correlation was found between Candida agglutination titres and density of Candida growth on culture. We conclude that an association exists between carcinoma esophagus and the occurrence of Candida in the esophagus.
Comments:
Comment in: Indian J Gastroenterol 1989 Oct;8(4):308-9
PMID: 2663710, UI: 89307411
J Med Vet Mycol 1989;27(5):277-94

Does Candida have a role in oral epithelial neoplasia?
Field EA, Field JK, Martin MV
Department of Clinical Dental Sciences, University of Liverpool, U.K.
Candida species are responsible for a wide variety of superficial infections of man [59] and the pathogenic role of these yeasts in many conditions has now been defined. There is, however, a great deal of controversy concerning the role of Candida species in the development of epithelial neoplasia.
Vaginal and cutaneous candidosis are relatively common but there is little firm clinical or epidemiological evidence to link them to cervical neoplasia or skin carcinoma [59]. The converse is true however for oral candidosis where chronic Candida infection and neoplasia have been strongly linked. The aim of this review is to explore and evaluate the experimental and epidemiological evidence supporting an association between Candida species and oral neoplasia.

Publication Types: Review, tutorial PMID: 2689621, UI: 90095753
Chung Hua Chung Liu Tsa Chih 1986 Jan;8(1):42-4
[Morphology of fungi in the slides prepared from esophageal balloons].
[Article in Chinese] Liu SF
1,762 cases were selected at random from 17,000 persons screened by esophageal balloon in 4 communes of Linxian County. The morphologic appearance of fungi was studied in 4 slides of each case selected.
According to the shape of clumps formed by fungi and bacteria in the slides, morphologic 4 types were seen: cotton-like, camel hair-like, hair-like and tree-branch-like. In the preliminary microscopic analysis, the following species of fungi were noted: Candida, Leptothrix, Actinomyces, Alternaria, Fusarium and Penicillium.
Some of the fungi in the slides may have been taken from the oral or pharyngeal cavity, which may be due to, at least in part, the poor oral hygiene in the population examined. A positive association was shown between the quantity of fungi in the slides and the esophageal epithelial dysplasia and carcinoma, but its biological significance should be studied further.
PMID: 3732022, UI: 86273952

Med Pediatr Oncol 1979;6(1):15-22
Fungal peritonitis and malignancy: report of two patients and review of the literature.
Kopelson G, Silva-Hutner M, Brown J
Two patients developed isolated Candida Albicans peritonitis in association with intraabdominal malignancy. Although additional factors predisposing to the development of fungal peritonitis were present, we postulate that tumor-related local factors permitted fungi to cross the gut wall and to enter the peritoneum, where the host immune status determined whether the infection spread. These two cases are the sixth and seventh reported cancer patients who developed fungal peritonitis, but the first two who had the fungal infection localized to the peritoneum; and this is the first report known to us specifically associating intraabdominal malignancy and fungal peritonitis. Patients who develop fungal peritonitis may have a primary or metastatic intraabdominal malignancy, and fungi should be considered as a cause of peritonitis in cancer patients.
Publication Types: Review PMID: 375052, UI: 79178083
Clin Infect Dis 1999 May;28(5):1071-9
Candidemia in cancer patients: a prospective, multicenter surveillance study by the Invasive Fungal Infection Group (IFIG) of the European Organization for Research and Treatment of Cancer.
Viscoli C, Girmenia C, Marinus A, Collette L, Martino P, Vandercam B, Doyen C, Lebeau B, Spence D, Krcmery V, De Pauw B,
Meunier F

University of Genova and National Institute for Cancer Research, Italy. viscolic@unige.it
[Medline record in process]
In a surveillance study of candidemia in cancer patients that was conducted by the European Organization for Research and Treatment of Cancer, 249 episodes were noted; Candida Albicans was isolated in 70% (63) of the 90 cases involving patients with solid tumors (tumor patients) and in 36% (58) of the 159 involving those with hematologic disease (hematology patients). Neutropenia in tumor patients and acute leukemia and antifungal prophylaxis in hematology patients were significantly associated with non-Albicans candidemia in a multivariate analysis. Overall 30-day mortality was 39% (97 of 249). In a univariate analysis, Candida glabrata was associated with the highest mortality rate (odds ratio, 2.66). Two multivariate analyses showed that mortality was associated with older age and severity of the underlying disease. Among hematology patients, additional factors associated with mortality were allogeneic bone marrow transplantation, septic shock, and lack of antifungal prophylaxis.
PMID: 10452637, UI: 99379706  
J Clin Microbiol 1988 Mar;26(3):429-32

Risk factors for candidemia in cancer patients: a case-control study.
Karabinis A, Hill C, Leclercq B, Tancrede C, Baume D, Andremont A
Service de Microbiologie Medicale, Institut Gustave-Roussy, Villejuif, France.
Risk factors for candidemia were analyzed in a case-control study of 30 cancer patients with candidemia and 58 controls. In a univariate analysis, previous surgery, neutropenia, central catheterization, chemotherapy, specific antibiotic treatments, and peripheral cultures positive for Candida spp. were associated with a significantly increased risk of candidemia. In a multivariate logistic model, the significant risk factors for candidemia were positive peripheral cultures for Candida spp. (P = 0.02), central catheterization (P = 0.03), and neutropenia (P = 0.05). These results should help to identify cancer patients with a high risk of candidemia, who should be given early systemic antifungal therapy.
PMID: 3356785, UI: 88187069 

Am J Med Sci 1993 Oct;306(4):225-32
Fungemia in patients with leukemia.
Martino P, Girmenia C, Micozzi A, Raccah R, Gentile G, Venditti M, Mandelli F
Department of Human Biopathology in Hematology, University La Sapienza, Rome, Italy.
A nine-year retrospective study on fungemia in patients with leukemia was conducted. A total of 79 episodes of fungemia in 77 patients with leukemia were documented. Candida parapsilosis fungemia was associated more frequently with the presence of a central venous line and to the use of parenteral nutrition than the other fungal species (p = 0.00026 and p = 0.01, respectively). The same fungus was isolated from both blood and surveillance cultures in 95% of Candida Albicans and in 89% of Candida tropicalis fungemia (p < 0.01 and p = 0.02, respectively). The neutropenia and fungus colonization that resulted was associated significantly with the presence of invasive disease (p = 0.0024 and p = 0.0028, respectively).
Conversely, central venous catheterization and parenteral nutrition appeared to be associated with episodes without deep tissue invasion (p = 0.000037 and p = 0.001, respectively). Invasive mycosis due to the fungus isolated from blood was documented in 51 patients with a mortality rate of 69%, whereas in 20 patients without invasive mycosis, mortality rate was 21% (p = 0.000059).
In patients with fungemia, related or unrelated to the presence of a central venous catheter, mortality was 24% and 64%, respectively (p = 0.00042). Mortality was highest with C. tropicalis (p = 0.0017) and lowest with C. parapsilosis (p = 0.057). Severe neutropenia (polymorphonuclears < 100/mmc) appeared associated with a higher mortality rate (p = 0.012), whereas the recovery of neutropenia was related adversely to a fatal outcome (p < 0.01). With antifungal therapy, there was no statistically significant difference whether antifungal therapy was given or not.
PMID: 8213890, UI: 94027136

Support Care Cancer 1993 Sep;1(5):240-4
Diagnosis and treatment of invasive fungal infections in cancer patients.
Martino P, Girmenia C
Department of Human Biopathology, University La Sapienza, Rome, Italy.
Fungal infections continue to cause major complications in cancer patients. With the increasing use of aggressive chemotherapy causing prolonged granulocytopenia, and the progress made in the prophylaxis and treatment of bacterial infections, the risk of invasive mycoses has increased, particularly in patients with hematological malignancies. The prognosis of these infections is poor unless they are diagnosed and treated promptly. Early diagnosis, particularly in neutropenic cancer patients, is often difficult and antifungal therapy is frequently unsuccessful because it is not instituted until the infection is in an advanced, fatal phase. In order to reduce the mortality associated with invasive fungal infections, antifungal therapy, usually amphotericin B, has been empirically carried out in neutropenic patients with fever unresponsive to broad-spectrum antibacterial therapy. However, the absence of a marker of the fungal infection, the frequent occurrence in these patients of non-infective fever, which does not require any antimicrobial therapy, and the possible toxicity of amphotericin B represent the major limits of empiric antifungal therapy. In view of the above, the study of improved and less toxic antifungal agents, and the evaluation of new clinical and laboratory methods for an early diagnosis, have been the major goals in research on the opportunistic invasive fungal infections in the last years.
Publication Types:Review, tutorial  PMID: 8156233, UI: 94207611

Eur J Clin Microbiol Infect Dis 1995 Sep;14(9):768-74
An autopsy study of systemic fungal infections in patients with hematologic malignancies.
Jandrlic M, Kalenic S, Labar B, Nemet D, Jakic-Razumovic J, Mrsic M, Plecko V, Bogdanic V
Department of Microbiology, Zagreb University Hospital, Croatia.
The aim of this study was to determine the incidence of fungal infections detected on autopsy in a group of 40 patients with hematologic malignancies treated with intensive chemotherapy or bone marrow transplantation, and to evaluate the risk factors for fungal infections. A control group included 38 patients with nonhematologic diseases and without granulocytopenia but with at least one of the known risk factors for fungal infections. Standard histopathological and microbiological methods were used. A higher incidence of invasive fungal infections was found in patients with hematologic malignancies as compared to the control group (p < 0.01).
The predominant causes of fungal infections were Candida Albicans and Aspergillus spp. The incidence of fungal infections caused by Aspergillus was higher (p < 0.05) in patients with hematologic malignancies than in the control group. The independent risk factors for fungal infections were fungal colonization, number of antibiotics and duration of antibiotic therapy, duration of fever and skin rash.
A higher proportion of fungal infections was diagnosed on autopsy than during the patients' life (p < 0.01).
PMID: 8536724, UI: 96120944 

Hematol Oncol 1986 Apr-Jun;4(2):129-34
Diagnosis and treatment of fungal infections in patients with hematologic malignancies.
Radaelli F, Cortelezzi A, Zocchi L, Castagnone D, Baldini L, Colombi M, Mozzana R
A diagnosis of deep-seated mycosis was made in 54 patients with hematologic malignancies, severe neutropenia and fever, based on a set of clinical and laboratory criteria. Standardized antifungal treatment was started in 31 patients who seven days after onset of fever had not responded to antibiotics; the fungal infection was cured in 13, all of whom had a simultaneous remission of neutropenia, whereas the other 18 who did not respond to antifungal treatment, all had a falling or static neutrophil count. None of the 23 patients who were given no or inadequate antifungal treatment survived regardless of the neutrophil count and/or phase of the hematologic disease. We discuss the suitability of utilizing empirical criteria for a diagnosis of disseminated fungal infection as a basis for starting antifungal therapy in this type of patient.
PMID: 3744304, UI: 86302397  

S Afr J Surg 1990 Mar;28(1):26-7
Pancreatic candidiasis. A case report.
Mannell A, Obers V
Department of Surgery, School of Pathology, South African Institute for Medical Research, Johannesburg.
A rare case of pancreatic candidiasis is described. The patient presented with weight loss, obstructive jaundice and a mass in the head of the pancreas. Intra-operative fine-needle aspiration cytology was consistent with a well-differentiated adenocarcinoma of the pancreas and a radical pancreaticoduodenectomy was performed. However, histological examination of the resected specimen revealed acute-on-chronic pancreatitis complicated by candidiasis with no evidence of malignant disease. The association between this variety of pancreatic candidiasis and pancreatic abscesses due to Candida Albicans in acute pancreatitis is discussed.
Tratto dai lavori di: Dott. Tullio Simoncini - Medico Oncologo e Specialista in Diabete e Malattie del Ricambio 
vedi anche Cancro e Medicina Naturale

Commento NdR: